Microdosimetry is a technique used to measure the stochastic(process that evolves in a random way) distribution of energy deposited by radiation at microscopic sites. It can help determine how energy is transferred inside cancer cells.
In study, three sensitive volumes (SVs) of different thicknesses have been used.
Lineal energy is the amount of energy deposited in a given volume of matter by a single energy-deposition event, divided by the mean chord length of that volume.
lineal energy dose distribution d(y): It describes the probability density of the energy deposited in a volume by ionizing radiation.
f(y) is the lineal energy probability density function and ¯y(F) its expectation value, called frequency-mean lineal energy.
The microdosimeter measures current pulses proportional to the energy deposited by a single-event.
Double linearinsed method
alin is the linearised signal amplitude, ach is the signal amplitude in acquisition-channels units and mA,mB and q are the three linearisation coefficients. aT is a free parameter.
The final calibration in lineal energy was then obtained according to the carbon-edge method. The carbon-edge method is calculated from the stopping power values of carbon ions. Stopping power in medical physics is the average amount of energy a material absorbs from a charged particle as it moves through the material.
The calibrated data obtained are eventually organised in the form of a histogram with logarithmic lineal energy.
By calculating first order approximation of taylor series, Final uncertainty was measured by
water-equivalent depth uncertainty was measured in study.
The thickness of the sensitive volumes (SVs) in microdosimetry significantly influences the radiation quality measurements.
Thinner detectors are more sensitive to high-energy events but are affected by noise and lower energy thresholds. Thicker detectors can better capture a broader spectrum of radiation, especially in regions dominated by secondary particles.
Source: https://iopscience.iop.org/article/10.1088/1361-6560/ad965e
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